Boiling and changing the water removes the psychoactive compounds as well as the ones that keep you on the toilet all day if you’ve done it correctly (both are water-soluble). At that point it’s just a culinary mushroom.
People who are “detoxifying” it to use as a drug bake it at a low temperature which does a poor job of removing any of the toxic or psychoactive compounds so they get a bad high and end up on the toilet half a day (seriously, just order some cube spores or something if IDing good actives is too hard).



I can practically hear Cecil reading this in an overly cheerful tone on an episode of Welcome to Nightvale.